C. elegans takes out the trash
نویسندگان
چکیده
منابع مشابه
OTU takes the chains OUT.
ERα LBD structures may explain instability in the absence of ligand or with specific ligands 1,2,7,9. Nettles et al. 5 address this instability through use of a specific point mutation, Y537S, which stabilizes H12 in an agonist con-formation and is shown to overcome misfold-ing of the apo-ERα LBD. One might predict that stabilizing H12 on top of the ligand binding cavity with the Y537S mutation...
متن کاملIt takes nerves to fight infections: insights on neuro-immune interactions from C. elegans.
The innate immune response is evoked as a consequence of interactions between invading foreign infectious agents and host immune cells. A successful innate immune response is pivotal in maintaining the delicate balance between health and disease; an insufficient response results in infection, whereas an excessive response results in prolonged inflammation and tissue damage. Alterations in the s...
متن کاملWASP takes the sting out of SCAR mutants
WASP takes the sting out of SCAR mutants V eltman et al. reveal how one actin regulator can fi ll in for another to maintain cell protrusion and migration. The Arp2/3 complex stimulates actin assembly at several different sites within the cell. WASP family proteins activate the complex at clathrin-coated pits undergoing endocytosis, whereas SCAR/WAVE proteins stimulate Arp2/3's activity at the ...
متن کاملReducing gravity takes the bounce out of running.
In gravity below Earth-normal, a person should be able to take higher leaps in running. We asked 10 subjects to run on a treadmill in five levels of simulated reduced gravity and optically tracked centre-of-mass kinematics. Subjects consistently reduced ballistic height compared with running in normal gravity. We explain this trend by considering the vertical take-off velocity (defined as maxim...
متن کاملThe C. elegans intestine.
The intestine is one of the major organs in C. elegans and is largely responsible for food digestion and assimilation as well as the synthesis and storage of macromolecules. In addition, the intestine is emerging as a powerful experimental system in which to study such universal biological phenomena as vesicular trafficking, biochemical clocks, stress responses and aging. The present chapter de...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Lab Animal
سال: 2017
ISSN: 0093-7355,1548-4475
DOI: 10.1038/laban.1264